Transcutaneous electrical acupoint stimulation of Lie que (LU7)-Qu chi (LI11)-Nei guan (PC6)-He gu (LI4) can significantly decrease the intraoperative consumption of remifentanil in patients undergoing video-assisted thoracoscopic lobectomy, to a similar level as Xin shu (BL15)-Fei shu (BL13)-PC6-LI4 (2)

Electroacupuncture at Lie que inhibits expression of protein kinases A, C and G in myocardial ischemic rats. Thus beneficially regulating cells and improving outcomes. Nei guan showed a stronger beneficial effect (3)

Transcutaneous acupoint electrical stimulation combined with dexmedetomidine at Nei guan (PC6), Lie que (LU7), and Yun men (LU2) could effectively maintain stable hemodynamics of intracranial aneurysmal subarachnoid hemorrhage patients undergoing intervention by regulating their serum levels of S100β and neuron specific enolase, systolic blood pressure, diastolic blood pressure, mean arterial pressure, and heart rate (4).

Acupuncture at Zhao hai (KI 6), Lie que (LU 7), He gu (LI 4) and San yin jiao (SP 6) can reduce uterine tension and maintain a stable environment during pregnancy in rats (5).

The combination of Zhao hai (KI6) and Lie que can help with generalised anxiety disorder (6)

Electroacupuncture at Lie que, Chi ze (LU5), and Zu san li (ST36) can lessen the lung injury induced by severe acute pancreatitis, increasing blood oxygenation, and the mechanism may be related to the decreased TNF-α and increased IL-10 value (7).

Acupuncture at LU5, LU7, LI4 and PC6 can maintain hemodynamic stability, reduce the stress response during intubation and extubation, improve the quality of anesthesia recovery, and decrease the incidence of postoperative complications in patients undergoing video-assisted thoracoscopic surgery (8)

Patients receiving transcutaneous electric acupoint stimulation at He gu (LI4), Lie que and Nei guan (PC6) compared with the controls, had lower cough scores and requirement of lidocaine and fentanyl and significantly higher postprocedural plasma β-endorphin levels when undergoing bronchoscopy. Total procedure duration, time for passage of the bronchoscope through the vocal cords, and systolic and diastolic blood pressure levels were all also less for those receiving the acupuncture (9)

Acupuncture at LU5, LU7, LI4, PC6 prevented such a sharp stress response in general anaesthesia, lowering blood pressure, heart rate, plasma cortisol and catecholamine and respiratory changes (10).

1. Yiu, EML., Li, N., & Chan, KMK. (2019) Anti-inflammatory effect of acupuncture in treating voice problems. 31st World Congress of the International Association of Logopedics & Phoniatrics (IALP) 2019, Taipei, Taiwan, 18-22 August 2019, Available at: https://hub.hku.hk/handle/10722/274213 
2. Peng, WP., Huang, Shun., Liang, HS., Feng Y. (2014) Comparison of intraoperative opioids-sparing effects of transcutaneous electrical stimulation of different acupoints in patients undergoing video-assisted thoracoscopic lobectomy. Chinese Journal of Anesthesiology; (12): 62-64, 2014. Available at: https://pesquisa.bvsalud.org/portal/resource/pt/wpr-446812 
3. Wang Y, Li D, Dai JY, et al. (2015). Effect of electro-acupuncture at Neiguan (PC6) and Lieque (LU7) on the expression of protein kinases in cardiomyocytes of myocardial ischemia rats. Chinese Journal of Integrated Traditional and Western Medicine, 2015, Mar;35(3):338-342. Available at: https://europepmc.org/article/med/25951641
4. Li, L., Yu, J., Mu, R., & Dong, S. (2017). Clinical effect of electroacupuncture on lung injury patients caused by severe acute pancreatitis. Evidence-based Complementary and Alternative Medicine, 2017, 1–6. https://doi.org/10.1155/2017/3162851 
5. Kim LW, Zhu J. (2008). Effects of acupuncture at “open” or “close” time and in “host” or “guest” sequence on uterine contraction in late pregnancy rats. Acupuncture Research. 2008 Oct;33(5):316-320. Available at: https://europepmc.org/article/med/19097503
6. C. Lini, X. Zhao, X. Liu and W. Fu,(2013). Observation on the mechanism of acupuncture treatment for generalized anxiety disorder using Lieque(LU7), Zhaohai(KI6) as the main acupoints. IEEE International Conference on Bioinformatics and Biomedicine, Shanghai, China, 2013, pp. 134-137, doi: 10.1109/BIBM.2013.6732657. 
7. Zhi-Yan, Y., Zhang, Y., Zhang, H., Zhao, X., Hua, W., He, S., Liu, J., & Liu, T. (2021). Effects of Transcutaneous Electrical Acupoint Stimulation on Stress Response during Intubation and Extubation in Patients Undergoing Video-Assisted Thoracoscopic Surgery: A Prospective, Randomized Controlled Trial. Evidence-based Complementary and Alternative Medicine, 2021, 1–8. https://doi.org/10.1155/2021/1098915 
8. Zhang, W., Yang, Y.-X., Yu, W., & Qi, S.-H. (2019). Cough suppression during flexible bronchoscopy using transcutaneous electric acupoint stimulation: a randomized controlled study. Evidence-based Complementary and Alternative Medicine, 2019. https://www.hindawi.com/journals/ecam/2019/5650413/. 
9. Yuan J, Wu Y, Li JY, et al. (2015). Protection of Transcutaneous Acupoint Electrical Stimulation for Brain Injury Undergoing Intervention: a Clinical Observation. Chinese Journal of Integrated Traditional and Western Medicine. 2015 Aug;35(8):971-974. Available at: https://europepmc.org/article/med/26485913
10. Yu, H., Geng, W., & Tang, H. (2009). [Preventive effect of transcutaneous electro-acupuncture on the intratracheal extubation stress response in general anesthesia of patients with breast cancer undergoing modified radical mastectomy]. Chinese Journal of Integrated Traditional and Western Medicine, 29(11), 990–992. https://pubmed.ncbi.nlm.nih.gov/20329608/