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Increasing studies suggested sympathetic nerve plays a key role in modulating sensory transmission by sprouting or coupling with sensory neuron/nociceptor in the peripheral, forming the functional structure of the sympathetic-sensory coupling.

Neuroanatomy evidence showed nociceptors innervated in acupoints contribute to the mechanism of acupuncture point sensitisation.

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J Pain Res. 2023;16:2997-3004. Published 2023 Aug 30. doi:10.2147/JPR.S424841

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